[18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi

Nuray Yıldız, Deniz Kıvrakdal Özkul
304 53




Bu çalışmada, F18[FDG] sentezi için gerekli olan olan 18F üretiminde kullanılmış  [18O]H2O’deki, organik safsızlıkların giderilmesi için ozonlama, ultrasonikasyon ve damıtma yöntemleri ayrı ayrı ve birleştirilmiş olarak örneklere uygulanmıştır.

Organik safsızlıkların giderilmesi için belirlenen yöntemler ilk olarak hazırlanan model çözeltilere uygulanmıştır. Sonuçlar  ozon+ultrasonikasyon yönteminin ışınlanmış [18O]H2O’i saflaştırmak için en uygun yöntem olduğunu göstermiştir. Bu yöntemle saflaştırılan [18O]H2O ile [18F]flor ve [18F]FDG üretimi yapılmış, saflaştırılmış [18O]H2O ile % 69 verim elde edilirken, yeni [18O]H2O ile % 72 verim elde edilmiştir. Elde edilen sonuçlar ışınlanmış [18O]H2O içindeki safsızlıklar giderilerek, kliniklerde  tekrar kullanılabileceğini göstermiştir.

Anahtar kelimeler

[18O]H2O, [18 F] Flor, siklotron, ultrasonikasyon, ozonlama

Tam metin:



Moon, W., Oh, S., Cheon, J. ve Chae, W., “Simple purification of recovered [18O]H2O by UV, ozone and solid-phase extraction methods”, Applied Radiation and Isotopes , Cilt 65, No 6, 635-40, 2007.

Fawdry, R. M., “A simple effective method for estimating the [18O] enrichment of water mixtures”, Applied Radiation and Isotopes Cilt 60, 23-26, 2004.

Kitano, H., Magata, Y., Tanaka, A. ve Mukaı, T,. “ Performance assessment of O-18 water purifier”, Annals of Nuclear Medicine, Cilt 15, No.1, 75-78, 2001

Nishijima, K., Kugea, Y., Tsukamotob, E. ve Sekic, K., “Increased [18F]2-fluoro- deoxy-d-glucose ([18F]FDG) yield with recycled target [18O]water: factors affecting the [18F]FDG yield”, Applied Radiation and Isotopes Cilt 57, 43-39, 2002.

Ito, S., Sakane, H., Deji, S. Ve Saze, T.,” Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesi”, Applied Radiation and Isotopes Cilt 64, 298- 305, 2006.

Huang, B., Channing, M., Plascjak, P. ve Kiesewetter, D.,” Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography”, Nuclear Medicine and Biology, Cilt 30, 785-790, 2003.

Asti, M., Grassi, E., Sghedoni, R. ve De Pietri, G. . “Purification by ozonolysis of

O enriched water after cyclotron ırradiation and the utilization of the purified

water for the purification [18F]FDG” Applied Radiation and Isotopes, 65, 831-835,

Twenson, T.J., Berridge, M.S., Bolomey, L., vd.,. “Routine production of reactive flüorine-18 flouride salts from an oxygen-18 water target”, Nuclear Medicine and Biology Cilt 15, 499-504, 1988.

Berridge, M.S. ve Kjellström, R., “ Design and use of silver targets for [18F]flouride production”, Applied Radiation and Isotopes, Cilt 50, 699-705, 1999.

Weber, K., Marx, H., Vierling, J., Wittstadt, U. ve Eisenhut, M., “Electrolytic purification of [18O ] water. J. Labeled”, Compounds Radio-Pharmaceuticals, Cilt 46 (Suppl. 1) S279, 2003.

Mangner, T.J., Mulholland, G.K., Toorongian, S.A., Jewett, D.M. ve Kilbourn, M.R., “Purification of used O-18 target water by photochemical combustion”, Journal of Nuclear Medicine, Cilt 33, 982–983, 1992.

Armstrong, F.A., Williams, P.M. and Strickland, D.H.,” Photo-oxidation of organic matter in seawater by ultra-violet radiation, analytical and other applications”, Nature 211, 481-484. 1966.

Hernandez, R., Zappi, M., Colucci J. ve Jones, R., “ Comparing the performance of various advanced oxidation processes for treatment of acetone contaminated water”, Journal of Hazardous Materials, Cilt 92, 33–50, 2002

Park, H.S., Hwang, T.M., Kang, J.W., Choi, H., ve Oh, H.J., 2001.” Characterization of raw water for the ozone application measuring ozone consumption rate”. Water Research, Cilt 11, 2607–2614, 2001.

Goel, M., Hongqiang, H., Mujumdar, A.S. ve Ray M.B. ,”Sonochemical

decomposition of volatile and non-volatile organic compounds—a comparative

study”, Water Research, Cilt 38, 4247–4261, 2004.

Jyothi, K.P. Suguna Yesodharan, Yesodharan E.P., “Ultrasound (US), Ultraviolet light (UV) and combination (US + UV) assisted semiconductor catalysed degradation of organic pollutants in water: Oscillation in the concentration of hydrogen peroxide formed in situ”, Ultrasonic Sonochemistry, Cilt 21, 1787-1796, 2014.

Mahammuni, N.N. ve Adewuyi Y.G., “Advanced oxidation processes (AOPs) involving ultrasound for waste water treatment: A review with emphasis on cost estimation”, Ultrasonic Sonochemistry Cilt 17, 990-1003, 2010.

Beckett, M.A. ve Hua, I.,”Impact of Ultrasonic Frequency on Aqueous

Sonoluminescence and Sonochemistry”. J. Phys. Chem. A., Cilt 105, No 15, 3796-3802, 2001.

Schwarz, S.W., McCarthy, T.J., King, N., vd.” FDG PETtrace MicroLab: average [18F]FDG E.O.S. activity compared to the source of the [18O]water used” Proceedings of the Seventh Workshop on Targetry and Target Chemistry, pp. 246–247, 1997.

Masten, S.J. ve Davies, H.R.,” The use of ozonization to degrade organic contaminants in wastewaters”, Environmental Science and Technology, Cilt 28, No

, 180-185, 1994.

Naffrechoux, E., Chanoux, S., Petrier, C. ve Suptil, J.,” Sonochemical and photochemical oxidation of organic matter”, Ultrasonics Sonochemistry, Cilt 7,

–259, 2000.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.