[18F]Flor üretiminde hedef olarak kullanılan [18O]H2O içindeki organik safsızlıkların giderimi

Nuray Yıldız, Deniz Kıvrakdal Özkul
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Bu çalışmada, F18[FDG] sentezi için gerekli olan olan 18F üretiminde kullanılmış  [18O]H2O’deki, organik safsızlıkların giderilmesi için ozonlama, ultrasonikasyon ve damıtma yöntemleri ayrı ayrı ve birleştirilmiş olarak örneklere uygulanmıştır.

Organik safsızlıkların giderilmesi için belirlenen yöntemler ilk olarak hazırlanan model çözeltilere uygulanmıştır. Sonuçlar  ozon+ultrasonikasyon yönteminin ışınlanmış [18O]H2O’i saflaştırmak için en uygun yöntem olduğunu göstermiştir. Bu yöntemle saflaştırılan [18O]H2O ile [18F]flor ve [18F]FDG üretimi yapılmış, saflaştırılmış [18O]H2O ile % 69 verim elde edilirken, yeni [18O]H2O ile % 72 verim elde edilmiştir. Elde edilen sonuçlar ışınlanmış [18O]H2O içindeki safsızlıklar giderilerek, kliniklerde  tekrar kullanılabileceğini göstermiştir.

Anahtar kelimeler

[18O]H2O, [18 F] Flor, siklotron, ultrasonikasyon, ozonlama

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